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Dexrazoxane hydrochloride

CAS No. 149003-01-0

Dexrazoxane hydrochloride ( ICRF-187 hydrochloride )

Catalog No. M12061 CAS No. 149003-01-0

A derivative of EDTA that chelates iron and reduces the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 64 In Stock
50MG 83 In Stock
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200MG 169 In Stock
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Biological Information

  • Product Name
    Dexrazoxane hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A derivative of EDTA that chelates iron and reduces the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals.
  • Description
    A derivative of EDTA that chelates iron and reduces the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals; protects the heart against the cardiotoxic side effects of chemotherapeutic drugs.Chemotherapeutic Agents Approved
  • Synonyms
    ICRF-187 hydrochloride
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Cancer
  • Indication
    Chemotherapeutic

Chemical Information

  • CAS Number
    149003-01-0
  • Formula Weight
    304.73
  • Molecular Formula
    C11H17ClN4O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(CN(C[C@@H](N1CC(NC(C1)=O)=O)C)C2)NC2=O.[H]Cl
  • Chemical Name
    1,3-Piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-, hydrochloride (1:)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lipshultz SE, et al. N Engl J Med. 2004 Jul 8;351(2):145-53.
2. Bjelogrlic SK, et al. Exp Biol Med (Maywood). 2007 Dec;232(11):1414-24.
3. Jones RL, et al. Expert Rev Cardiovasc Ther. 2008 Nov;6(10):1311-7.
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